Inhibition of CArbonic Anhydrase in Combination With Platinum and Etoposide-based Radiochemotherapy in Patients With Localized Small Cell Lung Cancer

• Status: Recruiting
• Trial end date: 2023-11-30

Summary

The investigators propose to study the carbonic anhydrase inhibition (acetazolamide) associated with concomitant radiochemotherapy in localized small cell lung cancer due to:

1. The over-expression of carbonic anhydrases in this type of cancer,

2. The Anti-tumor effect in preclinical acetazolamide in various tumor lines including neuroendocrine tumor lines,

3. The observed synergy between irradiation and inhibition of carbonic anhydrases,

4. Potential anti-tumor immune effect caused by decreased extracellular acidity.

• Phase: Phase 1

Details

• Lead Sponsor: Centre Antoine Lacassagne
• Treatments: Acetazolamide; Etoposide; Etoposide phosphate