Inhaled Steroids for the Treatment of Early Pediatric Acute Respiratory Distress Syndrome
Status:
Recruiting
Trial end date:
2022-01-31
Target enrollment:
Participant gender:
Summary
The purpose of this study is to show that inhaled steroids in patient with PARDS can decrease
the days on mechanical ventilator measured by ventilator-free days,to improve the oxygenation
index (OI) or oxygenation saturation index (OSI) in patients receiving inhaled steroids and
to show the relevance and feasibility of a larger study by assessing the hypothesis in a
small cohort of patients. Patient will be treated for a maximum of 10 days. Secondary
objectives are to reduce the length of stay (LOS) in the pediatric intensive care unit (PICU)
and hospital admissions; to show less inflammation in the patients receiving inhaled steroids
by measuring inflammatory markers from tracheal aspirates like Interleukin (IL6, IL8, tumor
necrosis factor (TNF) α, matrix metalloproteinase8 (MMP8) and matrix metalloproteinase9
(MMP9). Lastly, to show that inhaled steroids can improve residual lung disease evaluated by
Pulmonary Function Test (PFTs) and Impulse Oscillometry (IOS).
Phase:
Phase 2
Details
Lead Sponsor:
The University of Texas Health Science Center, Houston