Inhaled Nitric Oxide in Brain Injury

• Status: Recruiting
• Trial end date: 2021-10-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will evaluate the changes in respiratory mechanics following traumatic brain injury and determine the effect of inhaled nitric oxide on gas exchange.

• Phase: Phase 3
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Cincinnati
• Treatments: Nitric Oxide

Criteria

Inclusion Criteria:

• Hospital admission with traumatic brain injury (penetrating or blunt)

• Requirement for mechanical ventilation

• Glasgow Coma Score > 3

Exclusion Criteria:

• Brain death

• Expected survival < 48 hours

• Air leak (bronchopleural fistula, tracheal injury)

• Current inspired oxygen concentration (FiO2) > 0.65

• Hemodynamic instability (systolic blood pressure < 100 mm Hg, cardiac arrhythmia)

• Uncontrolled intracranial pressure (> 20 mm Hg)

• Spinal cord injury with hypotension

• Severe acute respiratory distress syndrome (ARDS) (PaO2/FiO2 < 100)

• Chest abbreviated injury score (AIS) > 3

• First rib fracture

• Flail chest