Inhaled Isopropyl Alcohol for Treatment of Nausea

• Status: Recruiting
• Trial end date: 2023-06-30
• Target enrollment: 0
• Participant gender: All

Summary

To determine the efficacy of inhaled isopropyl alcohol in treating nausea/vomiting among pediatric patients compared with the conventional ondansetron, or placebo treatment in a tertiary care pediatric emergency department.

• Phase: Phase 2/Phase 3
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: State University of New York at Buffalo
• Treatments: Ondansetron

Criteria

Inclusion Criteria:

• Patients with a chief complaint of nausea or vomiting

• Ages 7-178 years, both sexes

• Weight ≥ 15 kg

• Baxter Animated Retching Faces (BARF) nausea severity score ≥ 4/10

Exclusion Criteria:

• 1. Require IV access

• Inability to breathe in/out through the nose

• Anosmia (self- or parental report)

• Allergy to isopropyl alcohol or ondansetron

• Current or history of alcohol abuse

• Inability to communicate feeling nauseous

• Inability to follow directions regarding taking deep breaths through the nose

• Known prolonged QT interval

• Pregnancy

• Received antiemetics within the last 8 hours

• Currently taking apomorphine