Inhaled Ibuprofen to Treat COVID-19

• Status: Recruiting
• Trial end date: 2021-01-01
• Target enrollment: 0
• Participant gender: All

Summary

The study aims to evaluate the reduction in severity and progression of lung injury with inhaled ibuprofen in patients with severe acute respiratory syndrome due to SARS-CoV-2 virus.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Química Luar SRL
• Collaborators: Centro de Excelencia en Productos y Procesos Córdoba; National Council of Scientific and Technical Research, Argentina
• Treatments: Ibuprofen

Criteria

Inclusion Criteria:

1. Provision of written informed consent by the patient OR by the patient's Legal Representative.

2. Confirmed or suspected SARS-CoV-2 infection;

3. Pneumonia without criteria of severity.

4. With some of the following conditions:

• Diabetes.

• Cardiovascular disease.

• Chronic kidney disease.

• Chronic obstructive pulmonary disease.

• Structural diseases of the lung

• Immunocompromise.

5. Patient who presents negative results by rtPCR for SARS CoV-2, in case of being highly suspicious, the patient may receive it empirically until the results are obtained.

6. No unstable bronchial asthma

Exclusion Criteria:

1. The doctor considers that participation in the Program is not the best for patients or for any condition that prevents the Program from being followed safely.

2. Patients with a history of unstable bronchial asthma

3. The patient is allergic to ibuprofen or any of the compounds in the preparation.

4. Hypersensitivity to the drug, nasal polyps syndrome, angioedema or bronchospasm against aspirin or other NSAIDs.

5. Pregnant or lactating woman, or positive pregnancy test on a pre-dose exam.

6. Patient who is expected to be transferred to another place other than the place where the Program starts, within 7 days of starting it.