The primary objective of the study is to investigate the effect of inhaled budesonide on the
incidence of AMS. The primary study question to ask is:
1. Does inhaled budesonide reduce the incidence of AMS after rapid and active ascent to 4559
m?
In addition, the secondary study questions to ask are:
1. Does inhaled budesonide reduce the severity of AMS after rapid and active ascent to 4559
m?
2. Are the effects of inhaled budesonide on AMS incidence and severity related to its
plasma concentration?
Study medication Inhaled budesonide at 2 different concentrations (2 x 200 µg, 2 x 800 µg)
versus placebo
Study design
- Prospective, controlled, single-center study on 51 healthy volunteers at 4559 m [Capanna
Regina Margherita (Margherita Hut), Italy]
- With regard to the intervention (inhaled budesonide) double-blinded and randomized