Influences of Propofol and Sevoflurane Anesthesia in Brain Tumor
Status:
Not yet recruiting
Trial end date:
2025-11-30
Target enrollment:
Participant gender:
Summary
In the preoperative waiting area, the patients are randomly assigned and divided into two
groups according to the allocation sequence table (corresponding to 1:1 randomization)
generated by the computer. The propofol group was both induced and maintained at an
effect-site concentration (Ce) of 2.0-4.0 mcg/mL by a target-controlled infusion (TCI)
system. The sevoflurane group was maintained via sevoflurane vaporizer between 1% and 3%
(target minimum alveolar concentration of 0.7-1.3). The following patient data were recorded,
the type of anesthesia, sex, age at the time of surgery, preoperative Karnofsky performance
status (KPS) score and functional capacity, the postoperative complications within 30 days
(according Clavien-Dindo classification), American Society of Anesthesiologists(ASA) physical
status scores, tumor size, intraoperative blood loss/transfusion, duration of surgery,
duration of anesthesia, total opioid (remifentanil/fentanyl/ propofol) use, postoperative
radiation therapy, postoperative chemotherapy, postoperative concurrent chemoradiotherapy,
the presence of disease progression, and 6-month, 1-year, and 3-year overall survival and
Karnofsky performance status score were recorded.
Phase:
Phase 4
Details
Lead Sponsor:
Kaohsiung Medical University Chung-Ho Memorial Hospital