Influence of the Autonomic Nervous System in Response to Exercise in Hypertensive Individuals
Status:
Recruiting
Trial end date:
2021-12-23
Target enrollment:
Participant gender:
Summary
Systemic arterial hypertension (SAH) has a direct association with endothelial dysfunction
and major cardiovascular events. Evidence points to possible benefits of aerobic training in
the endothelial function analyzed by the flow mediated dilation technique (flow mediated
dilatation - FMD) in individuals with SAH. However, little is known about the influence of
the autonomic nervous system (ANS) on the results of brachial artery FMD after different
types of acute exercise in individuals with SAH. Thus, the objective of the research is to
analyze the influence of the ANS on the FMD of the brachial artery of individuals with SAH
after a session of aerobic (EA), resistance (ER) and combined (EC) exercise. For this,
thirty-nine hypertensive individuals aged 35 to 55 years will be recruited and will be
randomized to 2 sessions of AS, ER or EC. Also, within each modality, they will be randomized
to α1-adrenergic block (Doxazosin 0.05 mg / kg-1) or placebo. The FMD will be performed by
ultrasound 10 minutes before, as well as 10, 40 and 70 minutes after the exercise sessions
and the autonomic control will be monitored (Finometer) for 10 minutes before each FMD.
Arterial stiffness will also be analyzed, using the pulse wave velocity (PWV) by the Complior
Analyzer. It is expected to demonstrate with this research the influence of the ANS on the
FMD of the brachial artery in individuals with SAH in different physical exercises. This
knowledge contributes to a better training prescription in this population.