Influence of a Medicinal Cannabinoid Agonist on Responses to Food Images and Food Intake

• Status: Unknown status
• Trial end date: 2017-04-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to examine the influence of a medicinal cannabinoid agonist versus placebo on behavioural and gut peptide responses to food images and food intake.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Universitaire Ziekenhuizen Leuven
• Treatments: Cannabinoid Receptor Agonists; Dronabinol

Criteria

Inclusion Criteria:

For healthy volunteers:

1. 20 ≤ BMI ≤ 25

2. Age 18-60

3. Right handed

4. Stable body weight for at least 3 consecutive months at start of study and no history of behavioural, therapeutic or surgical treatment aiming at or leading to weight loss/gain

For obese subjects:

1. BMI > 30

2. Age 18-60

3. Right handed

4. Stable body weight for at least 3 consecutive months at start of the study and no behavioural, therapeutic or surgical treatment aiming at or leading to weight loss/gain for at least 3 consecutive months

For FD patients:

1. FD diagnosis according to 'Rome III' criteria

2. Age 18-60

3. Right handed

4. 5% weight loss since onset of symptoms

Exclusion Criteria:

1. Medical conditions (current or history):

• Abdominal/thoracic surgery except appendectomy

• Gastrointestinal, endocrine (especially diabetes), or neurological diseases

• Cardiovascular, respiratory, renal or urinary diseases

• Hypertension

• Food or drug allergies

• Head trauma with loss of consciousness

2. Psychiatric disorders:

• Eating disorders

• Psychotic disorders

• Major depressive disorder

• Somatoform disorder

3. Medication use:

• No history of cannabis use or any other drug of abuse for at least 12 months prior to the study

• All medication except oral contraception;

4. Known allergy to dronabinol and/or sesam oil

5. Pregnancy, plans to conceive or refusal to take adequate precaution to avoid pregnancy

6. Subjects who refuse to abstain from driving during the study