Influence of Ubrogepant and Sumatriptan on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin
Status:
Recruiting
Trial end date:
2023-03-15
Target enrollment:
Participant gender:
Summary
The involvement of calcitonin gene-related peptide (CGRP) in the cinnamaldehyde-induced
dermal blood flow increase and in the mechanism of action of triptans will be investigated.
The capsaicin-induced dermal blood flow will be incorporated as a positive control; histamine
skin pricks as a negative control. Changes in dermal blood flow will be measured with laser
speckle contrast imaging.