Influence of Stimulant Medication on Brain Processes for Decision Making in Attention Deficit Hyperactivity Disorder
Status:
Completed
Trial end date:
2015-06-01
Target enrollment:
Participant gender:
Summary
The goal of this trial is to investigate the cognitive- and brain-mechanisms underlying
decision making (DM) and learning in young adults with Attention-Deficit/Hyperactivity
Disorder (ADHD) as well as the modulation of task-related and task-independent brain
activation by methylphenidate. The study aims at using a double-blinded, placebo controlled,
cross-over, withdrawal design to study the effects of ADHD and methylphenidate in both a
behavioural study investigating cognitive effects on decision making and instrumental
learning, and a functional MRI (fMRI) study investigating the effects on brain mechanisms
during decision making alone. A secondary objective of the trial is to measure the effect of
adult ADHD and methylphenidate on cerebral perfusion. This will be done through applying a
novel arterial spin labelling MRI-technique on the participants in the fMRI arm of the study.
Phase:
Phase 4
Details
Lead Sponsor:
Mats Fredriksen
Collaborators:
Norwegian Institute of Public Health The Hospital of Vestfold The Research Council of Norway