Influence of Sevoflurane and Propofol on Maximum Muscular Strength, Speed of Contraction and Relaxation
Status:
Not yet recruiting
Trial end date:
2023-06-30
Target enrollment:
Participant gender:
Summary
Many drugs have an influence on neuromuscular transmission. In clinical practice,
neuromuscular blocking agents are commonly used, but even in the absence of neuromuscular
blocking agents, anesthetic drugs can influence neuromuscular transmission. Especially
volatile anesthetic agents have a clinical impact on neuromuscular transmission, they have
been shown to prolong and deepen the effect of neuromuscular blocking agents. But even in the
absence of neuromuscular blocking agents, volatile anesthetics can impair neuromuscular
transmission. One mechanism of action is the desensitization of the acetylcholine receptors
by shifting them from a normal to a desensitized state. This effect can weaken neuromuscular
transmission by reducing the margin of safety that normally exists at the neuromuscular
junction, or can cause an apparent increase in the capacity of neuromuscular blocking agents
to block transmission.
In this study, the influence of sevoflurane and propofol on the maximum force, maximum speed
of contraction and relaxation will be measured at the adductor pollicis in patients having
general anesthesia without the use of neuromuscular blocking agents. Maximum force and speed
of contraction and relaxation will be measured before and after anesthesia by either
sevoflurane or propofol. Primary outcome is the influence of either anesthetic agent on
maximum muscular force and speed of contraction - relaxation, and if this influence is
greater for volatile anesthetic agents than for intravenous anesthetic agents.