Influence of Prostaglandins on Ocular Blood Flow in Glaucoma Patients
Status:
Completed
Trial end date:
2005-02-01
Target enrollment:
Participant gender:
Summary
Vasoactivity of topical drugs may be of prognostic relevance in glaucoma. There is very
little information for a major class, the prostaglandin analogues with regard to this aspect.
The purpose of this study is to compare the effect of travoprost 0.004% and latanoprost
0.005% on choroidal blood flow and retinal vascular diameter in glaucoma patients. After
washout of current topical medication, intraocular pressure (IOP) in both eyes (Goldmann
applanation tonometry), choroidal blood flow (laser Doppler flowmetry) and retinal vessel
diameter (Retinal Vessel Analyzer) in one randomly selected eye will be measured at baseline,
after two weeks and after 4 weeks of treatment with travoprost or latanoprost QD, in a
randomized, double masked 2-way cross-over study in 20 open angle glaucoma patients.