Influence of Propofol on Alveolar Macrophage in Asthmatic Patients
Status:
Completed
Trial end date:
2009-03-01
Target enrollment:
Participant gender:
Summary
The change of airway responsiveness and alveolar macrophage (AM) immunity occurs during the
pathogenesis of asthma. Macrophage-associated airway protection in patients with asthma is
affected positively or negatively by propofol general anesthesia. The investigators
hypothesized that the effects of propofol on asthmatic AMs and corresponding airway
reactivity in vivo is different from the in vitro research. Through in vivo airway
hyperresponsiveness (AHR) observation and clinical investigation of AM immune functions from
asthma patients undergoing propofol general anesthesia to clarify the precise effects of
propofol on AM immunity, and to provide theoretical basis for the clinical administration of
propofol in asthmatic patients. This would optimize the practice of clinical anesthesia,
especially for those with the tendency of AHR.