Influence of Pantoprazole on Human Myocardial Contractility at Patients With Congestive Heart Failure
Status:
Withdrawn
Trial end date:
2008-12-01
Target enrollment:
Participant gender:
Summary
Recently literature revealed facts, that show H+/K+ ATPase expression is not limited tot he
stomach. H+/K+ ATPase was also found in smooth muscle cells and in other tissues (McCabe,
R.D. et al., Am J Physiol. 1992). For myocard a localisation is only proven for rats yet
(Beisvag, V. et al., Acta Physiol Scand. 2003). Moreover biochemical hints lead us to a
highly probability of a myocardial H+/K+ ATPase (Nagashima, R. et al., Jpn Heart J. 1999).