Overview

Influence of Mechanical Ventilation Modes on the Efficacy of Nebulized Bronchodilator

Status:
Unknown status
Trial end date:
2019-12-10
Target enrollment:
0
Participant gender:
All
Summary
Aerosol therapy is widely used in intensive care in critically ill patients that use mechanical ventilation (MV). However, there is a lack of standardization about aerosol performance in this group of patients. Thus, this study aims to evaluate the effect of nebulization performed in different ventilatory modes on lung function and regional pulmonary distribution of critical patients with chronic obstructive pulmonary disease. It is a clinical trial, crossover, randomized, controlled and blind. Three interventions with bronchodilators will be performed: in the Pressure Controlled Ventilation mode (PCV) with positive end expiratory pressure (PEEP) = 85% of autoPEEP, in the PCV mode with PEEP = 15 cmH2Oand in the Pressure Support Mode (PSV). Pulmonary function data will be evaluated through Electrical Impedance Tomography to evaluate the efficacy of the bronchodilator in different ventilatory modes.
Phase:
N/A
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Universidade Federal do Rio Grande do Norte
Treatments:
Albuterol
Bromides
Bronchodilator Agents
Ipratropium
Criteria
Inclusion Criteria:

Patients with asthma or chronic obstructive pulmonary disease (COPD) Invasive mechanical
ventilation Hemodynamically stable

Exclusion Criteria:

Prescribed metered dose inhaler (MDI) or intravenous bronchodilators Undrained pneumothorax
Bronchopleural fistula Chest trauma Tracheoesophageal fistula Tracheal granulomas Tracheal
stenosis PEEP dependence

Contraindicated disconnection of the MV

Endotracheal tube diameter less than 7.5

Do not make part of the protocol of daily sedation

No regular ventilatory drive when with out sedation

Do not reach a minimum tidal volume 6 ml/kg with a maximum peak pressure (PIP) of 35 cmH2O
(centimeter of water) during MV.

Do not use the same MV modes that will be tested in this study