Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects

• Status: Completed
• Trial end date: 2011-08-01
• Target enrollment: 0
• Participant gender: All

Summary

This project aims at identifying novel pharmacological targets for the treatment of memory disorders.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Prof. Dominique de Quervain, MD
• Collaborator: Clinical Trial Unit, University Hospital Basel, Switzerland
• Treatments: Diphenhydramine; Losartan; Promethazine

Criteria

Inclusion Criteria:

• healthy

• native or fluent German-speaking

• BMI between 19 and 27 kg/m2

• able and willing to give written informed consent and comply with the requirements of the study protocol

• willing to donate saliva sample for DNA-analysis

• female: willing to perform a pregnancy test at the beginning of both test visits

Exclusion Criteria:

• acute or chronic psychiatric or somatic disorder

• pathological ECG

• known hypersensitivity to the IMP under investigation (losartan, diphenhydramine)

• hypotension (RR < 110/70 mmHg)

• bradycardia (< 50 bpm)

• pregnancy, breast-feeding

• long-term medication within last 3 months (oral contraceptives are disregarded)

• smoking (> 3 cigarettes per day)

• concurrent participation in another study

• participation in one of our previous studies using the same memory tests

• inability to read and understand the participant's information