Overview

Influence of Hydroxyehtyl Starch (HES) on Hemorehology, Coagulation and Elimination Kinetics

Status:
Completed

Trial end date:
2006-03-01

Target enrollment:
0

Participant gender:
All

Summary

The use of HES has been found clinically to improve patients with stroke if administered within a window period by means of hemodilution to improve rehology. We propose to see the effects of long term administraion of HES in the amounts required for treating stroke patients and study the effects on the kinetics of HES, its effects on coagulation and hemorheology.

Phase:

N/A

Accepts Healthy Volunteers?

Details

Lead Sponsor:

Nizam's Institute of Medical Sciences University, India

Criteria

Inclusion Criteria:

Age 18 - 70 yrs Clinical diagnosis of ischemic stroke No marked spontaneous improvement of
symptoms before randomization Written informed consent from nearest relative.

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Exclusion Criteria:

Pregnancy Allergy to HES Severe impairment of consciousness Previous stroke with persistent
ipsilateral deficits. Seizure at stroke onset. Intracranial neoplasm or AV malformation.
Cardiac insufficiency or pulmonary edema Myocardial infarction during the previous 3 months
or unstable angina. Severe dehydration Coagulation disorders. Uncontrolled Hypertension.
Laboratory findings reflecting severe anemia, renal insufficiency, thrombocytopenia or
hepatic insufficiency.

Participation in another clinical trial within the previous 2 months or concurrent
treatment with any other experimental drug.

SECONDARY EXCLUSION CRITERIA.

Cerebral CT at enrolment showing intracranial hemorrhage of any degree-