Influence of H1-antihistamines on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin.
Status:
Completed
Trial end date:
2020-03-12
Target enrollment:
Participant gender:
Summary
In order to validate the accuracy and reliability of the histamine skin prick model for
histaminergic itch and vasodilation, the dermal blood flow response induced by a histamine
skin prick will be evaluated after the administration of certain H1-antihistamines. Besides,
the influence of these H1-antihistamines on the dermal blood flow response induced by the
topical application of cinnamaldehyde and capsaicin will be evaluated. Changes in dermal
blood flow will be measured with laser speckle contrast imaging.