Influence of Glitazones on the Vasodilatory Effect of High-density Lipoprotein (HDL) Lipoproteins
Status:
Completed
Trial end date:
2012-03-01
Target enrollment:
Participant gender:
Summary
HDL from patients with type 2 diabetes show a significant reduction of their
endothelium-dependent vasodilatory effect.
The primary objective of the study is to analyze whether treatment with glitazones
(pioglitazone and rosiglitazone)may improve the endothelium-dependent vasodilatory effect of
HDL lipoproteins in patients with type 2 diabetes.
The secondary objectives are:
- to analyze the effect of glitazone treatment on phospholipase A2
- to look for possible differences between the effects of pioglitazone and those of
rosiglitazone
- to analyze the glycemic response to glitazone therapy according to clinical and
biological baseline characteristics.