Influence of Dexmedetomidine and Lidocaine on Opioid Consumption in Laparoscopic Intestine Resection
Status:
Completed
Trial end date:
2016-05-01
Target enrollment:
Participant gender:
Summary
Using combination of opioid analgesics and analgesics with different mechanism of action the
investigators can decrease the consumption of opioid analgesics and their side effects. The
investigators will use opioid analgesic fentanyl alone or in combination with dexmedetomidine
or lidocaine.The participants scheduled for laparoscopic intestine resection will be divided
in three groups: in the first group, the participants will receive single boluses of
fentanyl, in the second group, the participants will receive continuous infusion of lidocaine
and single boluses of fentanyl, and in the third group, the participants will receive
continuous infusion of dexmedetomidine and single boluses of fentanyl. Participants with
intraoperative infusion od dexmedetomidine or lidocaine will need less boluses of fentanyl
during the operation and less opioid analgesics after the operation in comparison to those
who will receive only fentanyl boluses. Better cognitive function after the operation is
expected in participants receiving dexmedetomidine infusion. There will be minimal incidence
of neuropathic pain because of minimal surgical injury of peripheral nerves in all groups of
patients.