Influence of Cytochrome P2B6 on Efavirenz Dose in HIV-infected Thai Patients
Status:
Unknown status
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Genetic polymorphisms of cytochrome P450 2B6 (CYP2B6) are associated with lower rate of EFV
metabolism and lead to high exposure, as well as a higher risk of neuropsychiatric adverse
event especially homozygous variant CYP2B6 *6/*6. This trial was designed to compare the
proportion of patients who had undetectable HIV RNA at 24 weeks after ART initiation between
patient who did CYP 2B6 guided EFV dose and who did not.