Influence of Central Nervous Insulin Sensitivity on Insulin Secretion
Status:
Completed
Trial end date:
2018-04-01
Target enrollment:
Participant gender:
Summary
Insulin resistance is a central pathophysiological component of type 2 diabetes and is
associated with a high risk of cardiovascular disease. The tissue in which it manifests are
mainly muscle, liver, and adipose tissue. Since the transport of glucose to the brain is
independent of insulin, this organ has traditionally not been studied in this regard. In
animal experiments, however, knockout of the insulin receptor in the brain leads to obesity
and peripheral insulin resistance. This finding of insulin action in the brain could also be
confirmed in human studies.
The investigators intend to investigate whether central nervous insulin action affects
insulin secretion in humans. For this purpose, nasal insulin and placebo are administered 15
minutes before a hyperglycemic hyperinsulinemic clamps, which stimulate insulin secretion.
Insulin sensitivity of the brain is measured by a an established protocol with functional
magnetic resonance imaging before and after nasal insulin administration.