Influence of Anesthetics on Clinical Outcome in Mitral and Aortic Valve Replacement in Adults
Status:
Completed
Trial end date:
2022-10-16
Target enrollment:
Participant gender:
Summary
Abstract Anaesthetic support for cardiac surgery significantly influences the course of the
intraoperative period and the success of the postoperative period. Total intravenous
anaesthesia and inhalation anaesthesia are the traditional methods of anaesthesia in cardiac
surgery. However, there are few studies assessing the effectiveness of surgical aggression
protection in cardiac surgery.
Objectives: To study the effect of anesthetics on clinical outcome after mitral and aortic
valve replacement in adults.
Methods. The data of 75 patients operated in the Cardiosurgery Department of the Medical
Center Hospital of the Presidential Administration of the Republic of Kazakhstan were
included in the study. All patients underwent mitral, aortic valve replacement/plasty under
cardiopulmonary bypass (CPB) conditions.
All patients were divided into 3 groups according to the type of anaesthesia: the first (1)
group patients anaesthetised with propofol (P), the second group with sevoflurane (S), and
the last one is with isoflurane (I).
To maintain anaesthesia in Group 1 propofol was used as anaesthetic in a dose of 6 mg/kg/h
intravenously on perfusion. In Group 2 the anaesthetic used was sevoflurane in a dose of
1.7-1.9 MAC. Group 3 used isoflurane in the dose of 1.1-1.2 MAC as anaesthetic. Statistical
analysis was done by the method of single factor analysis of variance and Kruskal Wallis
criterion.