Influence of Amphetamine-induced Sensitization on Dopamine Synthesis and Release
Status:
Recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
Patients with schizophrenia show enhanced dopamine synthesis capacity and release, an effect
that can be evoked in healthy subjects by repeated amphetamine administration. Therefore for
the first time the relationship between dopamine synthesis and release will be studied in
healthy subjects before and after amphetamine sensitization in order to better understand
adaptive mechanisms of the dopamine system.