Influence of Age, Sepsis and SLCO1A2 Polymorphisms on Rocuronium Pharmacokinetics

• Status: Completed
• Trial end date: 2015-12-01
• Target enrollment: 0
• Participant gender: All

Summary

This study aims to evaluate the influence of age and sepsis on in vivo activity of OATP1A2 using rocuronium (ROC) as a probe and evaluating the pharmacokinetics and pharmacodynamics in ASA I-III surgical patients. Thus, adult patients without sepsis (control group, n= 12), adult patients with sepsis (sepsis group, n= 12) and elderly patients without sepsis (elderly group, n= 12), all submitted to small to medium-sized surgeries who were induced with individual doses of rocuronium, fentanyl and propofol are being investigated.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Universidade Estadual Paulista Júlio de Mesquita Filho
• Collaborator: University of Sao Paulo
• Treatments: Anesthetics; Fentanyl; Midazolam; Propofol; Rocuronium

Criteria

Inclusion Criteria:

• Adult and elderly patients, both gender.

• Patients submitted to small to medium-sized surgeries.

• Patients who were induced with individual doses of rocuronium, fentanyl and propofol.

• Patients with normal renal function (creatinine clearance > 60 mL/min).

• Patients with normal liver function.

Exclusion Criteria:

• Patients who were in use of fluoxetine, carbamazepine, aminoglycoside antibiotics, OATP1A2 inhibitors.

• Patients with gastrointestinal and liver diseases, neuromuscular disorders.

• Patients who were in chronic use of drugs which alter rocuronium effect.