Influence of Age, Sepsis and SLCO1A2 Polymorphisms on Rocuronium Pharmacokinetics
Status:
Completed
Trial end date:
2015-12-01
Target enrollment:
Participant gender:
Summary
This study aims to evaluate the influence of age and sepsis on in vivo activity of OATP1A2
using rocuronium (ROC) as a probe and evaluating the pharmacokinetics and pharmacodynamics in
ASA I-III surgical patients. Thus, adult patients without sepsis (control group, n= 12),
adult patients with sepsis (sepsis group, n= 12) and elderly patients without sepsis (elderly
group, n= 12), all submitted to small to medium-sized surgeries who were induced with
individual doses of rocuronium, fentanyl and propofol are being investigated.
Phase:
Phase 4
Details
Lead Sponsor:
Universidade Estadual Paulista Júlio de Mesquita Filho