Influence of Administration Route of Testosterone on Male Fertility
Status:
Withdrawn
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
Exogenously administered testosterone will override the normal negative feedback of
endogenous testosterone on the hypothalamus and pituitary. Constantly, relatively high and
constant testosterone levels will cause a drop in FSH and LH production by the pituitary.
Since FSH and LH are signalling hormones to the testes, endogenous testosterone production
and spermatogenesis will be down-regulated. It is expected that intranasal dosing in the
morning will mimic the normal physiological pattern of testosterone production thereby
avoiding negative side-effects on spermatogenesis. Trans-dermal gels give testosterone levels
more or less constant over the day and will very likely have inhibitory effects on
spermatogenesis.
The main objective of this study is to show that twice daily intranasal dosing does not have,
or has a smaller inhibitory effect on spermatogenesis in comparison to transdermal
testosterone gels.