Infliximab as Induction Therapy in Early Rheumatoid Arthritis (IDEA)

• Status: Completed
• Trial end date: 2011-02-01
• Target enrollment: 0
• Participant gender: All

Summary

This is a placebo controlled randomised clinical trial.Patients attending Yorkshire Early Arthritis Clinics and diagnosed with rheumatoid arthritis with symptom duration of 3-12 months will be recruited. They will be randomised to blinded therapy with either methotrexate and intravenous corticosteroid at baseline, or methotrexate and intravenous infliximab according to the standard treatment regime. Patients will be followed regularly, and at each visit, if the patients are not in remission, they will be given an intramuscular injection of corticosteroid. After 26 weeks, all patients will be unblinded and those with an inadequate treatment response will be treated according to a dose escalation algorithm until they achieve remission. Those in remission will continue on blinded therapy and if 6 months of remission is achieved the intravenous agent (infliximab or placebo) will be withdrawn.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Leeds
• Treatments: Folic Acid; Infliximab; Methotrexate; Methylprednisolone; Methylprednisolone acetate; Methylprednisolone Hemisuccinate; Prednisolone; Prednisolone acetate; Prednisolone hemisuccinate; Prednisolone phosphate; Vitamin B Complex; Vitamins

Criteria

Inclusion Criteria:

• Men & Women 18-80 years of age.

• Fulfil 1987 ACR criteria for RA.

• Symptoms of > 3 months and < 12 months duration.

• Men and women must use adequate birth control measures for the duration of the study and should continue such precautions for 6 months after receiving the last infusion or dose of methotrexate.

• The patient must be able to adhere to the study visit schedule and other protocol requirements.

• The patient must be capable of giving informed consent and the consent must be obtained prior to any screening procedures.

• Must have a chest radiograph within 3 months prior to first treatment dose with no evidence of malignancy, infection or fibrosis.

• Are considered eligible according to the tuberculosis (TB) eligibility assessment.

• Active disease as defined by DAS > 2.4.

• TNF therapy naïve.

• DMARD therapy naïve.

• Negative hepatitis B and C screening tests within 3 months prior to screening.

Exclusion Criteria:

• Women who are pregnant, nursing, or men or women planning pregnancy within 24 months after screening.

• Use of any investigational (unlicensed) drug within 1 month prior to screening or within 5 half-lives of the investigational agent, whichever is longer.

• Previous or current treatment with any other therapeutic agent targeted at reducing TNF.

• Prior treatment with any DMARD.

• Serious infections (such as pneumonia or pyelonephritis) in the previous 3 months.

• Documented HIV infection.

• Hepatitis- B or Hepatitis-C serology positive (must be checked within 3 months prior to screening).

• Are considered ineligible according to the TB eligibility assessment.

• Have or have had an opportunistic infection within 6 months prior to screening.

• Significant haematological or biochemical abnormality.

• Have current signs or symptoms of severe, progressive or uncontrolled renal, hepatic, hematologic, gastrointestinal, endocrine, pulmonary, cardiac, neurologic, or cerebral disease.

• Concomitant congestive heart failure, including medically controlled asymptomatic patients.

• Presence of a transplanted organ (with the exception of a corneal transplant > 3 months prior to screening).

• Malignancy within the past 5 years.

• History of lymphoproliferative disease including lymphoma, or signs and symptoms suggestive of possible lymphoproliferative disease.

• Known recent substance abuse (drug or alcohol).

• Poor tolerability of venipuncture or lack of adequate venous access for required blood sampling during the study period.

• Have a chest radiograph at screening that shows evidence of malignancy, infection, or any abnormalities suggestive of TB.

• Have a positive Mantoux test or evidence of active TB infection, or recent close contact with an individual with active TB.

• Previous oral, IM, IA or IV corticosteroids within 1 month prior to baseline.

• Receiving treatment with anakinra.

• Contra-indications to methotrexate, infliximab or steroids.