Inflammatory Response to Opioid Versus Opioid Free Anesthesia
Status:
Completed
Trial end date:
2021-03-29
Target enrollment:
Participant gender:
Summary
Anesthetic agents, including opioids can modulate the altered immune function in patients
with obesity through mechanisms that involve the expression and release of cytokines. For
this reason, anesthetic care in patients with obesity remains controversial. Therefore, the
aim of the study was to compare the effect of opioid-containing anesthesia vs opioid-free
anesthesia using the Cortínez-Sepúlveda model on serum levels of IL-6, IL-1β and TNF-α before
and after surgery in obese patients undergoing bypass surgery.
Methods: A randomized cross-sectional study of 40 unrelated obese adults was performed in the
Anesthesiology and Bariatric Surgery Service at the Civil Hospital of Guadalajara "Dr. Juan
I. Menchaca". Before undergoing laparoscopic Roux-en-Y gastric bypass, patients were randomly
assigned to two anesthesia groups: opiod-containing (n=20) or opioid-free (n=20). The opioid
used in the opioid-containing anesthesia group was fentanyl. To characterize the disposition
of intravenous propofol for the target-controlled infusion technique in obese patients, the
Cortínez-Sepúlveda pharmacokinetic model was used. Body mass was determined to the nearest
0.05kg using a balance scale (Seca 703; Seca, Hamburg, Germany). Blood samples were taken
before and immediately after surgery and cytokine serum levels were determined with ELISA
kits. Statistical analyses were performed using the IBM Statistical Package for the Social
Sciences software package version 20.0 (IBM Corp., Armonk, NY, USA).