Inflammatory Axis and Sirtuins' in Overweight Pre-diabetics Patients
Status:
Completed
Trial end date:
2018-01-01
Target enrollment:
Participant gender:
Summary
In obese patients the superficial adipose tissue works as an endocrine active tissue to
express different cytokines, and multiple molecular pathways implied in the cross talking
with different part of the human body, such as the cardiovascular system. To date, adipocytes
and adipose tissue-derived macrophages and adipose tissue synthesize, and secrete several
cytokines, and sirtuins. In this setting, the excess of body fat is linked to heart
contractile dysfunction. All these pathways are differently expressed in obese diabetic
patients as compared to obese non diabetic patients. Intriguingly, in diabetic obese patients
the hyper-expression of inflammatory cytokines is associated to a hypo-expression of
sirtuins. Therefore, this molecular pattern in diabetic obese patients may correlate to
altered myocardial performance, and to the development of heart failure disease. In this
study authors will evaluate at baseline by peripheral blood samples and by the abdominal fat
tissue, the expression of cytokines and sirtuins comparing pre-diabetics obese patients vs.
non pre-diabetics obese patients.