Induction With Misoprostol: Oral Mucosa Versus Vaginal Epithelium (IMPROVE)
Status:
Active, not recruiting
Trial end date:
2021-12-01
Target enrollment:
Participant gender:
Summary
The primary objective of this study is to compare the efficacy and safety of vaginal and
buccal misoprostol for women undergoing labor induction at greater than or equal to 37+ 0
completed weeks gestation. Thus, the investigators have both efficacy and a safety primary
outcomes.
The secondary objective of this study is to assess the pharmacokinetic(PK) parameters with
these two routes of administration in a sub-cohort of this trial. The long term objective of
this line of research is to inform providers' clinical decision making for the large number
of women having labor induction. By providing robust PK and pharmacodynamic (PD) evaluation,
clinical outcomes data for these two routes of administration, clinicians will be informed
for evidence-based decisions about the preferred route of administration of misoprostol.