Induction Treatment Followed by Immunosuppression Withdrawal in Liver Transplantation: A Comparative Trial
Status:
Terminated
Trial end date:
1969-12-31
Target enrollment:
Participant gender:
Summary
This is a randomized, controlled trial in liver transplantation in which conventional
immunosuppressive treatment will be compared with a therapeutic strategy consisting in
pre-transplant antibody-mediated T cell depletion followed by reduced calcineurin inhibitor
usage. The working hypothesis is that antibody induction followed by calcineurin inhibitor
minimization may promote development of tolerogenic mechanisms allowing the eventual
withdrawal of all immunosuppressive therapy.