Induction Chemotherapy Followed by Surgery for Locally Advanced Head and Neck Cancer
Status:
Active, not recruiting
Trial end date:
2021-06-30
Target enrollment:
Participant gender:
Summary
The objective of this study is to assess the efficacy of induction chemotherapy followed by
transoral surgical treatment and neck dissection, in definitive management of moderately
advanced oropharyngeal squamous cell carcinoma. The surgical treatment will carry out
Transoral Robotic Surgery (TORS) or Transoral Laser Microsurgery (TLM) for the primary tumor,
and neck dissection for the management of cervical lymph nodes.
The primary outcome measure will be disease specific survival (DSS). The secondary oncologic
outcome measures will be locoregional control, relapse free survival, overall survival, and
Quality of Life (QOL).