Background: Indomethacin is frequently used as a tocolytic, however there is currently only
scant evidence to support its efficacy.
Goals: To delay preterm delivery by 48 hours and to examine longer latency periods and
maternal and neonatal outcomes Methods: Randomized placebo-controlled trial of indomethacin
for tocolysis. Women with a singleton pregnancy between 23w0d and 31w6d in preterm labor
randomly assigned to 50mg indomethacin by mouth followed by 25mg by mouth every 6hour for 48
hours or placebo. Patients receive betamethasone for fetal lung maturity, if not previously
administered, and magnesium sulfate for neuroprotection. Ultrasound performed before
initiation of study drug and after completion of study medication for amniotic fluid index
and fetal cardiac assessment.