Following signed informed consent, patients scheduled for elective cardiac surgery were
randomly assigned to one of 3 groups to be given acetaminophen, Indomethacin or a combination
of both immediately following induction and then at 6, 12, 18 & 24 hours following surgery.
Our primary outcome measure was the amount of blood drained from the mediastinal tubes and
chest drains. Secondary outcome measures included conventional blood coagulation indices as
well as other measures of clotting as indicated by thromboelastography (TEG). Other secondary
outcome measures included consumption of morphine equivalents and pain scores.