Indocyanine Green Fluorescent Molecular Imaging of the Gastrointestinal Tract
Status:
Completed
Trial end date:
2013-04-01
Target enrollment:
Participant gender:
Summary
Standard white light endoscopy involves the passage of a thin, flexible camera into the colon
from the anus. Although standard white light endoscopy can detect most polyps and
precancerous areas in the gastrointestinal tract and colon, many studies have shown that even
the most experienced doctors, under optimal conditions, can miss up to 15-25% of precancerous
areas. Thus, there remains a clear need to develop new methods of improving standard white
light endoscopy. We are investigating whether indocyanine green (ICG) can serve to highlight
areas which are precancerous when the colon is visualized with a special cameral which shines
fluorescent light. Information from other studies suggests that this ICG agent may help to
visualize blood vessels flowing to precancerous areas in the colon. We are looking at the
ability of ICG, in combination with an endoscope which shines fluorescent light, to visualize
precancerous areas in the colon.
Phase:
N/A
Details
Lead Sponsor:
Massachusetts General Hospital
Collaborators:
Damon Runyon Cancer Research Foundation Dana-Farber Cancer Institute National Cancer Institute (NCI)