Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
Status:
Completed
Trial end date:
2016-01-01
Target enrollment:
Participant gender:
Summary
This will be a pilot study of 9 patients undergoing standard-of-care clinically indicated
carotid endarterectomy. The nine patients will receive an injection of Indocyanine green
(ICG) at a dose of 0.25 mg/kg (maximum 25 mg) as an intravenous bolus.
Immediately following endarterectomy, the resected specimen will be immersed in normal
saline. Ex vivo fluorescence reflectance imaging (FRI) and immunohistochemistry will be
performed.
The investigators hypothesize that compared to controls, ICG-injected patients will
demonstrate increased ex vivo and microscopic ICG fluorescence signal within areas of plaque.