Overview

Individualized Obesity Pharmacotherapy

Status:
Active, not recruiting
Trial end date:
2022-07-01
Target enrollment:
0
Participant gender:
All
Summary
The researchers are trying to identify the specific characteristics (phenotypes) that may be useful to help select the right medication for weight loss.
Phase:
Phase 3
Accepts Healthy Volunteers?
No
Details
Lead Sponsor:
Mayo Clinic
Treatments:
Bupropion
Liraglutide
Naltrexone
Phentermine
Topiramate
Criteria
Inclusion criteria:

- Adults with obesity (BMI >30 Kg/m2); these will be otherwise healthy individuals with
no unstable psychiatric disease and controlled comorbidities or other diseases.

- Gender: Men or women. Women of childbearing potential will have negative pregnancy
tests within 48 hours of enrollment and before each radiation exposure.

Exclusion criteria

- Abdominal bariatric surgery

- Positive history of chronic gastrointestinal diseases, or systemic disease that could
affect gastrointestinal motility, or use of medications that may alter
gastrointestinal motility, appetite or absorption, e.g., orlistat, within the last 6
months.

- Significant untreated psychiatric dysfunction based upon screening with the Hospital
Anxiety and Depression Inventory (HAD), and the Questionnaire on Eating and Weight
Patterns (binge eating disorders and bulimia). If such a dysfunction is identified by
an anxiety or depression score >11 or difficulties with substance or eating disorders,
the participant will be excluded and given a referral letter to his/her primary care
doctor for further appraisal and follow-up.

- Hypersensitivity to any of the study medications.

- No contraindications to all FDA-approved medications