Individual Dosing of Levothyroxine After Thyroidectomy
Status:
Recruiting
Trial end date:
2023-06-10
Target enrollment:
Participant gender:
Summary
Recently, Zaborek et al. raised a Poisson regression model for levothyroxine(LT4) dosing
scheme to predict individual dose of LT4 after thyroidectomy: daily LT4
dose=e[2.02+0.01(W)-0.0037(A )-0.098(F)-0.01(B)+0.007(T)+0.108(I)-0.014(M), where W is the
weight of the patient (Kg), A is the age of the patient (years), and F is the gender (for
women 1, male is 0), B represents the patient's body mass index (BMI), T represents the
preoperative TSH level, I represents whether the patient takes iron preparations (1, if not
0), M represents whether the patient takes multivitamins/minerals (1, if not 0). We
demonstrated its value with our retrospective data in our center. Therefore, we intend to
carry out this randomized controlled trial in order to further evaluate the model. The
clinical significance of this method can provide a basis for the future use in clinical
optimization of individualized dosing.
Phase:
N/A
Details
Lead Sponsor:
Second Affiliated Hospital, School of Medicine, Zhejiang University