Indicated Prevention With Omega-3 Fatty Acids in Adolescents With 'At-Risk-Mental-State' for Psychosis
Status:
Completed
Trial end date:
2007-06-01
Target enrollment:
Participant gender:
Summary
Early intervention in psychosis might be associated with better outcomes. However,
intervention in the pre-psychotic phase has been questioned as, using current criteria, only
20-50% of individuals classified as prodromal develop a psychotic disorder within a 1-2 years
period. Treatment agents investigated in the pre-psychotic phase of schizophrenia and other
psychotic disorders should, therefore, not have major side effects. This proposal
investigates omega-3 fatty acids (1.2 gramm per day eicosapentaenoic acid/docosahexaenoic
acid;EPA/DHA) as a beneficial and possible preventive therapeutic agent in young people at
ultra high-risk for developing a psychotic disorder.