Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS

• Status: Recruiting
• Trial end date: 2023-06-07
• Target enrollment: 0
• Participant gender: Female

Summary

The investigators aim to conduct a double blind randomized clinical trial to study the independent and additive effects of micronutrients (Resveratrol, Acetyl-L Carnitine, L Arginine and COQ10 ) with Metformin in patients with PCOS .Women diagnosed with PCOS according to National Institute of Health( NIH) 2012 extension of European Society of Human Reproduction and Embryology /American Society of Reproductive Medicine ESHRE /ASRM 2003 criteria will be included according to a specific phenotype including Hyperandrogenism, Ovulatory dysfunction and Polycystic Ovarian Morphology. The investigators propose that by using combination therapy with micro supplements like Resveratrol, Acetyl-L Carnitine, L Arginine and COQ10 will produce greater improvement better than or at least comparable to Metformin in metabolic and endocrine profile of patients with PCOS.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Khyber Medical University Peshawar
• Treatments: Metformin; Resveratrol

Criteria

Inclusion Criteria:

• PCOS women aged 16 -45 years.Diagnosis of PCOS will be made according to NIH 2012 extension of ESHRE/ASRM 2003 criteria Identification of specific phenotype will be included

1. HA+OD+PCOM (Hyperandrogenism, Ovulatory dysfunctions, Polycystic ovarian morphology)

2. HA+OD

3. HA+PCOM

4. PCOM+OD

Exclusion Criteria:

1. Women with hyperprolactenemia

2. Diabetes Mellitus

3. Cushing syndrome

4. Androgen secreting tumours

5. Non classical congenital adrenal hyperplasia

6. History of seizures

7. Patients on anti coagulants, anti platelets ,isoproterenol ,antidepressants, potassium sparing diuretics

8. Pregnancy or use of contraceptives

9. Patients with thyroid disease

10. Patients on hormonal therapy -