Incretin Secretion in Women With Polycystic Ovary Syndrome (PCOS)
Status:
Terminated
Trial end date:
2006-05-01
Target enrollment:
Participant gender:
Summary
The incretin hormones are secreted from the gastrointestinal tract in response to nutrient
ingestion, and are responsible for 70 % of insulin secretion in response to glucose. The
incretin response is attenuated in subjects with type 2 diabetes and other conditions
associated with insulin resistance. Polycystic ovary syndrome (PCOS) is characterised by
irregular periods and increased androgen levels. It is the most common endocrine disorder
amongst young women at fertile age, and the most common cause of female infertility. Insulin
resistance plays an important role in the development of the disease, and women with PCOS are
at increased risk of developing tyoe 2 diabetes. the incretin hormones have not previously
been investigated in women with PCOS, and the purpose of the present study was to investigate
the secretion of the two most important incretin hormones Glucose-like peptide-1 (GLP-1) and
Glucose dependent insulinotropic peptide (GIP) during a three hour oral glucose tolerance
test.