Incorporation of Vitamin K Into Uremic Lipoproteins

• Status: Completed
• Trial end date: 2021-09-15
• Target enrollment: 0
• Participant gender: All

Summary

Chronic kidney disease (CKD) patients have an increased cardiovascular risk with corresponding cardiovascular calcifications. CKD patients exhibit a functional vitamin K deficiency. Calcification can be prevented by vitamin K intake. The aim of this study is to investigate the cause for the vitamin K deficiency beyond a diminished dietary vitamin K uptake.

• Phase: N/A
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: RWTH Aachen University
• Treatments: Vitamin K; Vitamin K 1; Vitamins

Criteria

Inclusion criteria

• Age ≥ 18 years

• Controls: adequate kidney function (GFR > 60 ml/min/1,73m2)

• Patients: chronic haemodialysis

• Written consent to take part in the study

Exclusion criteria

• Intake of vitamin K antagonists

• gastro-intestinal diseases interfering with vitamin K intake

• profound anemia with an Hb < 10 g/dl

• judicial or official commitment to an institution

• pregnancy and lactation