In Vivo Leptin Signaling in Humans After Acute Leptin Administration
Status:
Completed
Trial end date:
2017-01-01
Target enrollment:
Participant gender:
Summary
The purpose of this research study is to help us to better understand how leptin regulates
blood sugar levels. Leptin is a recently discovered hormone, which is made in fat cells.
Leptin is secreted by fat and acts as a signal to the brain to decrease appetite and
influences how the body regulates blood sugar levels. A synthetic form of leptin (A-100), an
investigational drug and has not yet been approved by the Food and Drug Administration (FDA),
will be administered to participants in this study. The expected duration of your
participation is 3 study visits, which will be spread over 3-4 weeks.
This study involves having fat and muscle biopsies after receiving leptin under local
anesthesia in the General Clinical Research Center (GCRC), surgical unit, and/or
Endocrinology exam room at the Beth Israel Deaconess Medical Center.