In Situ Erosion Study to Investigate the Effectiveness of an Experimental Toothpaste
Status:
Completed
Trial end date:
2018-01-16
Target enrollment:
Participant gender:
Summary
This will be a randomized, controlled, single center, single- blind, 3 period, 3 treatment,
cross-over, in situ design which consists of placing pre-eroded bovine enamel specimens intra
orally using a palatal appliance and testing the remineralizing performance of the
experimental (dentifrice containing 0.254 Percent weight by weight [%, w/w] sodium fluoride
(1150 parts per million [ppm] fluoride) and 5% KNO3 [potassium nitrate]), comparator
(dentifrice containing 0.454% w/w stannous fluoride (1100 ppm fluoride) and placebo (Fluoride
free placebo containing 5% KNO3 [0 ppm fluoride] ) dentifrices 2 and 4 hours (hrs) post
treatment application, based on surface micro hardness measurements. This study will be
carried out in healthy adults with a maxillary dental arch suitable for the retention of the
palatal appliance.