Improving Vitamin D Status In Cystic Fibrosis

• Status: Completed
• Trial end date: 2011-05-01
• Target enrollment: 0
• Participant gender: All

Summary

The purpose of this study is to establish an effective method to correct vitamin D deficiency in subjects with cystic fibrosis. The investigators will examine cholecalciferol, ergocalciferol and UV light.

• Phase: N/A
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: Atlanta VA Medical Center
• Collaborator: Emory University
• Treatments: Cholecalciferol; Ergocalciferols; Vitamin D; Vitamins

Criteria

Inclusion Criteria:

• Subjects seen initially at the Emory CF center between the months of September and December

• Age > 16, both males and females, confirmed cystic fibrosis by genetic testing or sweat testing, FEV1 > 40%.

Exclusion Criteria:

• History of lung transplant or awaiting lung transplantation

• Current hospitalization or greater than 6 hospitalizations/year

• History of malignancy, renal disease (calculated GFR < 50% reduced from normal), liver disease (AST or AST > 3 times upper limit of normal), greater than 10 mg of prednisone or equivalent, hypercalcemia

• History of easily burned skin after sunlight exposure, taking medications with may cause photosensitivity

• History of skin cancer or multiple moles or family history of skin cancer

• Moderate to severe vitamin D deficiency (25(OH)D ≤ 15 ng/ml).