Improving Safety of Antivenom in People Bitten by Snakes

• Status: Completed
• Trial end date: 2008-04-01
• Target enrollment: 0
• Participant gender: All

Summary

A study to increase the safety of polyvalent antivenom involving 1000 patients in three centres: low dose adrenaline, promethazine, & hydrocortisone (alone and in combination) to prevent acute adverse reactions to antivenom in people bitten by snakes: randomised, double blind, placebo-controlled trial.

• Phase: Phase 4
• Accepts Healthy Volunteers?: No

Details

• Lead Sponsor: University of Kelaniya
• Treatments: Antivenins; Cortisol succinate; Diphenhydramine; Epinephrine; Epinephryl borate; Hydrocortisone; Hydrocortisone 17-butyrate 21-propionate; Hydrocortisone acetate; Promethazine; Racepinephrine

Criteria

Inclusion Criteria:

• Above 12 years of age

• Patients admitted to hospital after snake bite in whom antivenom is indicated

• Patients who give informed consent

Exclusion Criteria:

• Patients who are pregnant or nursing

• Patients who are currently taking beta- or alpha-adrenoceptor antagonists, or tricyclic antidepressants

• Patients in whom adrenaline may be contraindicated (this may include patients with the following: history of ischaemic heart disease, stroke, uncontrolled hypertension, and tachyarrhythmias)