Overview

Improving PRegnancy Outcomes With Intermittent preVEntive Treatment in Africa

Status:
Completed
Trial end date:
2020-03-15
Target enrollment:
Participant gender:
Summary
This study evaluates the efficacy and safety of monthly intermittent preventive treatment using dihydroartemisinin piperaquine (DP) alone or in combination with azithromycin (AZ) compared to sulphadoxine-pyrimethamine (SP) for the prevention of malaria in pregnant women in the second and third trimester.
Phase:
Phase 3
Details
Lead Sponsor:
Liverpool School of Tropical Medicine
Collaborators:
Centers for Disease Control and Prevention
Foundation for Innovative New Diagnostics, Switzerland
Kenya Medical Research Institute
Kilimanjaro Christian Medical Centre, Tanzania
London School of Hygiene and Tropical Medicine
Malawi-Liverpool-Wellcome Trust Clinical Research Programme
National Institute for Medical Research, Tanzania
PATH
Tampere University
University College, London
University of Bergen
University of Copenhagen
University of Malawi College of Medicine
University of Massachusetts, Worcester
University of Melbourne
University of Toronto
Treatments:
Artemisinins
Artenimol
Azithromycin
Dihydroartemisinin
Fanasil, pyrimethamine drug combination
Piperaquine
Pyrimethamine
Sulfadoxine