Improving Learning-based Treatment of Cocaine Dependence With Medication

• Status: Completed
• Trial end date: 2013-03-01
• Target enrollment: 0
• Participant gender: All

Summary

This study will test the efficacy of d-cycloserine in enhancing response to learning-based treatment for cocaine dependence, specifically contingency management.

• Phase: Phase 2
• Accepts Healthy Volunteers?: Accepts Healthy Volunteers

Details

• Lead Sponsor: Johns Hopkins University
• Collaborator: National Institute on Drug Abuse (NIDA)
• Treatments: Cocaine; Cycloserine

Criteria

Inclusion Criteria:

• 18-60 years of age (> 60 due to age-related effects on cognitive functioning)

• Satisfy DSM-IV criteria for cocaine dependence (primarily crack)

• Able to complete all study measures

• Currently seeking treatment for cocaine dependence

Exclusion Criteria:

• Meets DSM-IV criteria for dependence on a drug other than cocaine or nicotine (may meet abuse criteria for other drugs)

• Pregnant, breast feeding, or planning to become pregnant within 3 months

• If female, do not agree to use an effective means of birth control during the course of treatment (via phone screen)

• History of seizure disorder, severe hepatic impairment, porphyria, serious head trauma, dementia, or significant cognitive impairment

• Diagnosis of current major psychiatric disorder besides substance dependence or abuse

• Reported use of DCS in the past year

• Illiteracy, as will be determined during in-person screening

• Concurrently prescribed or using ethionamide or isoniazid (both used to treat tuberculosis)

• Positive urine result for opioids at screening interview