Improvement of FeNO and FEF25-75 After Inhaled Corticosteroid Treatment of Asthma
Status:
Completed
Trial end date:
2010-07-01
Target enrollment:
Participant gender:
Summary
Abnormal lung function and high exhaled nitric oxide (FeNO) have been reported in
asymptomatic patients with asthma. The investigators aimed to assess whether FeNO and
FEF25-75 improve concurrently after treatment with inhaled corticosteroid (ICS) in patients
with controlled asthma. Geometric mean (GM) FeNO and spirometric values in patients 8 to 16
years of age who maintained asthma control without controller medication were compared with
healthy controls and patients with uncontrolled asthma who were also not receiving controller
medications. Patients with controlled asthma and high FeNO (> 25 ppb) were randomized to ICS
treatment or to remain untreated. Changes in spirometric values and GM FeNO from baseline
were evaluated after 6 weeks.